Pipeline Focused

Spoke’s expanding ingredient and finished consumer product portfolio includes our patent pending IsoCaps™ ingredient technology for use in beverages, beverage enhancers and topicals, SNAC for solid oral dosage forms with improved bioavailability, our Curēous™ beverage line, and Physik™ topical products. WaferTech™ is our device-based approach to adding functional ingredients to espresso and capsule-based coffee makers.

Ingredients

IsoCaps™

IsoCaps is Spoke Sciences' proprietary method of incorporating lipophilic substances into water dispersible nanoparticles. When formulated this way, very high concentrations of difficult to formulate ingredients can now be easily added to any beverage. For example, 1 ml of IsoCaps VIT100 contains 100% of the RDA for vitamins A, D, E and K. IsoCaps can be added with simple low energy mixing, are stable and virtually tasteless.

Finished Products

Curēous™ Beverages

Using IsoCaps, Spoke Sciences has formulated a line of world class beverages. With less than 100 calories per serving, no added sugars, and no artificial sweeteners, these ready to drink beverages have been expertly blended to deliver a satisfying, sophisticated experience. Available with and without CBD.

Cureous Blends Pipeline

Curēous™ Blends

Curēous Blends are concentrated versions of our IsoCaps, formulated to be added to the beverage of your choice. For the first time, consumers can easily add these ingredients simply by adding 1 ml or less of our Blends. For example, 100% of the RDA for vitamins A, D, E and K can added to any drink with I ml (~1/30th of an ounce). Curēous Blends are tasteless and readily disperse in water.

PHYSIK™ Topicals

Using IsoCaps, Spoke Sciences has created a growing line of Physik topical products aimed at musculoskeletal pain relief, sun care and general skin health. Through the use of IsoCaps, Physik products are elegant, water-based and completely non-greasy.

SNAC

Salcaprozate sodium or “SNAC” is a patented, absorption enhancing excipient that drastically improves the oral bioavailability of lipophilic active ingredients.  SNAC is already used in two marketed products – an over-the-counter medical food that improves the bioavailability of vitamin B12, and a blockbuster diabetes drug with the active ingredient semaglutide.  SNAC is covered by a global patent estate with issued patents in the US, Europe, Australia, Japan, Canada, Mexico, Korea and Israel.

Challenging lipophilic (non-water soluble) active ingredients can be combined with SNAC to make proprietary oral dosage forms with long patent life.  SNAC can also be used for life cycle management making oral dosage forms out of known actives currently administered by injection.  In short SNAC is ready for development with poorly absorbed nutritional supplements.

Spoke also owns an extensive dossier on SNAC including methods of manufacture, product feasibility analyses, and pre-clinical and clinical studies.  Among these are a human clinical study showing that SNAC increases cannabidiol (CBD) oral bioavailability by 6-fold compared to standard solid-filled capsules without SNAC, and another clinical study showing that SNAC increased oral tetrahydrocannabinol (THC) exposure by 2.3-fold compared to THC in ethanol. 

Spoke has also developed data validating SNAC’s mechanism of action which will support continued growth of Spoke’s SNAC patent portfolio.

WaferTech™

Wafertech is Spoke Sciences’ patent-pending system for incorporating lipophilic ingredients into prepared beverages like coffee or tea.  The Wafertech innovation infuses lipophilic active ingredients into any “porous substrate” such as a coffee filter or tea bag.  One innovative product example is a filter designed to fit a standard espresso machine in cafés.  The infused filter is placed inside the brewing “portafilter” underneath ground espresso, and the active ingredient is infused into the espresso drink with >80% extraction efficiency.  Wafertech is simple to use, eliminates machine fouling and ensures zero carryover from cup to cup.  The technology can also be readily applied to K-cup and other pod-based brewing systems.